Fallout 4 became way more fun when they introduced Survival Mode for just this reason. It forced you to set up a base and use it to prepare for your journey before setting out. Have a good night’s rest, have a big meal, plan your route, pack your bags with enough gear to get by without being overburdened.
Heading into the Glowing Sea, need to pack extra RadAway. I can complete these two quests on the way there, then loop around and do this quest on the way back. Should take me at least 4 days, so this many purified water bottles should suffice.
Days later, you finally make it back to base. You’re tired, you haven’t slept in a proper bed in ages. You ran out of water and RadAway on day 2, so you’re highly irradiated and thirsty. Your bag is packed with loot. You get home, crash in bed until noon the next day. Get clean, have a big breakfast, clean water, then spend the next couple of days relaxing, recovering. Sort through your loot, using materials you gathered to build up your base, upgrade weapons etc.
Then onto the next journey.