Playing fallout 4 was a pain with all the loading screens.
The world should be one big level so no loading screens during explorations ( possibly few exceptions when the situation suddenly change after a cut scene or something like that) 
What´s your hardware/config playing FO4?
Load/save works really smoth with PC and SSD. Much better than expected… 
Expect sleeping, waiting, fast travel, and entering dungons 
I’m so happy that the game will have one giant cell with no loading screens. For large interiors like dungeons I don’t mind them. I remember making a house in Oblivion’s Construction Set that had interior in the same cell as the landscape - making it at least barely playable was a nightmare due to it lowering framerate so severely.