So I was going to play as a complete bastard, killing a ton of generic NPCs (any unnamed NPC in the game).
The problem is that after a while they respawn, and THEY REMEMBER WHAT YOU DID!
This is very game breaking to say the least, specially when guards start chasing you for no reason at all, not to mention you reputation goes in the toilet.
PS. The Takedown is not working properly anymore (since 1.3.2 or 1.3.3) as the victim will ALWAYS see you and remembers what you did when it wakes up.
Both of these bugs are affecting stealth gameplay a ton, needs a fix ASAP.