At first sorry for my poor english…
If you got the CTD issue, try this:
Use a overclocking tool like MSI Afterburner etc. (depending on your GPU)
don’t overclock, just UNDERclock your GPU and RAM (GPU’s RAM of course) a few MHz!
Round about -48 MHz for GPU and -56 Mhz for RAM did the trick for me.
I’ve got a factory-set OC GPU and got the CTD issue at several games like Skyrim, GTA V, Max Payne etc.
With slightly undeclocking my GPU I don’t have this issue anymore…hope this helps…