After playing 39 hours, I now experience this issue.
I played for this time without game-breaking bugs, but now, the game will not load any more at all. It keeps me stuck in the loading screen after I selected the first option on Main Menu. Before, I never had any issues like this, I restarted my PC and the game multiple times.
This happens to every savegame on my first walkthrough (no idea if this is stated correctly, I am playing the game in German and do not know the correct words from the english Main Menu). When I start a new “career”, it will start ASAP, no problems. But even when I try to load my old savegame, it will get stuck on the loading screen.
If you imagine the loading icon as a clock, it will get stuck on a bit after the 3, like 16min or something, if that helps anything.
I experience sort of the same problem, but for me it wont load after i sleep or try to save the game. PS4
Same here on xboxone, only difference: after a couple of times restarting the game and the console too, the loading is going much further “on the clock” of the loading icon, still not loading tho